Cover Feature: An l‐RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis (ChemBioChem 18/2017),ChemBioChem

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Cover Feature: An l‐RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis (ChemBioChem 18/2017)
ChemBioChem ( IF 2.6 ) Pub Date : 2017-09-05 , DOI: 10.1002/cbic.201700453
Adam M. Kabza ₁ , Jonathan T. Sczepanski ₁

Affiliation

The inside cover picture shows an in vitro selection strategy for identifying l‐RNA aptamers (often referred to as Spiegelmers) containing non‐native nucleotides. Using this approach, we identified the first modified l‐RNA aptamer (MLRA), which is capable of binding a precursor microRNA (pre‐microRNA) hairpin with extremely high affinity and specificity. Binding of the target by the modified aptamer inhibits biogenesis of the corresponding microRNA, thus suggesting that MLRAs offer a robust strategy for targeting structured RNAs for biomedical applications. More information can be found in the communication by J. T. Sczepanski and A. M. Kabza on page 1824 in Issue 18, 2017 (DOI: 10.1002/cbic.201700362).

中文翻译：

封面人物：具有扩展的化学功能的l‐RNA适体，可抑制MicroRNA生物发生（ChemBioChem 18/2017）

封面图片显示了一种体外选择策略，用于鉴定包含非天然核苷酸的l- RNA适体（通常称为Spiegelmers）。使用这种方法，我们确定了第一个修饰的l- RNA适体（MLRA），它能够以极高的亲和力和特异性结合前体microRNA（pre-microRNA）发夹。修饰的适体与靶标的结合抑制了相应microRNA的生物发生，因此表明MLRA提供了针对生物医学应用中靶向结构化RNA的强大策略。有关更多信息，请参见2017年第18期的J.T.Sczepanski和A.M.Kabza的来信（第1824页）（DOI：10.1002 / cbic.201700362）。

更新日期：2017-09-05

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