A Eutectic Mixture of Natural Fatty Acids Can Serve as the Gating Material for Near‐Infrared‐Triggered Drug Release,Advanced Materials

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A Eutectic Mixture of Natural Fatty Acids Can Serve as the Gating Material for Near‐Infrared‐Triggered Drug Release
Advanced Materials ( IF 27.4 ) Pub Date : 2017-09-05 , DOI: 10.1002/adma.201703702
Chunlei Zhu ₁ , Da Huo ₁ , Qiaoshan Chen ₁ , Jiajia Xue ₁ , Song Shen ₁ , Younan Xia _{1,

2}

Affiliation

A smart release system responsive to near‐infrared (NIR) light is developed for intracellular drug delivery. The concept is demonstrated by coencapsulating doxorubicin (DOX) (an anticancer drug) and IR780 iodide (IR780) (an NIR‐absorbing dye) into nanoparticles made of a eutectic mixture of naturally occurring fatty acids. The eutectic mixture has a well‐defined melting point at 39 °C, and can be used as a biocompatible phase‐change material for NIR‐triggered drug release. The resultant nanoparticles exhibit prominent photothermal effect and quick drug release in response to NIR irradiation. Fluorescence microscopy analysis indicates that the DOX trapped in the nanoparticles can be efficiently released into the cytosol under NIR irradiation, resulting in enhanced anticancer activity. A new platform is thus offered for designing effective intracellular drug‐release systems, holding great promise for future cancer therapy.

中文翻译：

天然脂肪酸的低共熔混合物可以作为近红外触发药物释放的门控材料

开发了一种响应近红外 (NIR) 光的智能释放系统，用于细胞内药物输送。这一概念是通过将阿霉素 (DOX)（一种抗癌药物）和 IR780 碘化物 (IR780)（一种近红外吸收染料）共封装到由天然存在的脂肪酸的低共熔混合物制成的纳米颗粒中来证明的。该低共熔混合物具有明确的熔点（39°C），可用作近红外触发药物释放的生物相容性相变材料。所得纳米粒子表现出显着的光热效应和响应近红外辐射的快速药物释放。荧光显微镜分析表明，在近红外辐射下，纳米颗粒中捕获的 DOX 可以有效释放到细胞质中，从而增强抗癌活性。因此，为设计有效的细胞内药物释放系统提供了一个新的平台，为未来的癌症治疗带来了巨大的希望。

更新日期：2017-09-05

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