Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.

中文翻译：

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生酮饮食可以延长成年小鼠的寿命和健康寿命。

热量限制，无营养不良，可延长寿命，并与从糖酵解向β-氧化的转变有关。这项研究的目的是模仿低碳水化合物饮食的这种代谢变化，并确定这些饮食对小鼠寿命和健康的影响。C57BL / 6小鼠在12个月大时被分配为生酮，低碳水化合物或对照饮食，经过1或14个月的饮食干预后，可以保持其自然寿命或测试其生理功能。与对照组相比，生酮饮食（KD）显着提高了中位寿命和存活率。在老年小鼠中，只有那些消耗KD的小鼠才显示出生理功能的保持。KD以组织依赖性方式增加蛋白质乙酰化水平并调节mTORC1信号传导。