Hematopoietic stem cells (HSCs) have the extraordinary ability to both self-renew and generate all mature blood cell lineages. The ability to produce or expand patient-derived HSCs in vitro would greatly improve the outcome for patients with blood disorders that are currently treated with allogeneic HSC transplantation. Many laboratories have been working to identify the signals required for HSC emergence in their native environments to apply this knowledge in vitro. Recently, several signals traditionally known to underlie classical inflammation have emerged as essential regulators of HSC development. In this review we synthesize the findings that have established inflammatory cues as key regulators of HSC development.

造血干细胞（HSC）具有自我更新和产生所有成熟血细胞谱系的非凡能力。体外产生或扩增患者来源的HSC的能力将大大改善目前接受异体HSC移植治疗的血液病患者的预后。许多实验室一直在努力寻找在其原生环境中HSC出现所需的信号，以在体外应用该知识。近来，已经出现了传统上已知为经典炎症基础的几种信号，它们是HSC发展的重要调节剂。在这篇综述中，我们综合了将炎症线索作为HSC发育关键调节因子的发现。