Insulin-like growth factor 1 (IGF-1) influences cell proliferation and survival. In the extracellular environment, IGF-1 circulates bound to proteins (IGF-binding proteins; IGFBP), some of which have physiological effects that seem independent of IGF-1, including the brain (for example, IGFBP-3). We completed a systematic review of the association between dementia and IGF-1 and IGFBP-3, and a cross-sectional and longitudinal study designed to investigate if lower plasma concentration of these proteins increased the risk of prevalent and incident dementia. A total of 3967 men aged 71-89 years joined the study, of whom 535 (13.5%) showed evidence of prevalent cognitive impairment. The plasma concentrations of IGF-1 and IGFBP-3 were similar for men with and without cognitive impairment. The 3432 men free of cognitive impairment were then followed for up to 13 years. During this time 571 (16.6%) developed dementia. The plasma concentration of IGF-1 had no association with incident dementia. The doubling of the plasma concentration of IGFBP-3 decreased the hazard ratio of dementia by 23% (95% confidence interval=5-37%). The results were not affected by age, body mass index and history of smoking, diabetes, hypertension, coronary heart disease or stroke. If these findings are confirmed by others, the plasma concentration of IGFBP-3 could be used to improve the accuracy of predictive models of dementia and as a potential new factor to assist in the development of prevention and treatment strategies.

中文翻译：

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与胰岛素样生长因子和胰岛素样生长因子结合蛋白相关的普遍性痴呆和偶发性痴呆的风险3。

胰岛素样生长因子1（IGF-1）影响细胞增殖和存活。在细胞外环境中，IGF-1循环结合蛋白（IGF结合蛋白； IGFBP），其中某些蛋白具有似乎不依赖于IGF-1的生理效应，包括大脑（例如IGFBP-3）。我们完成了对痴呆症与IGF-1和IGFBP-3之间关联的系统评价，并进行了横断面和纵向研究，旨在研究这些蛋白的较低血浆浓度是否会增加患痴呆症和患痴呆症的风险。共有3967名年龄在71-89岁的男性参加了该研究，其中535名（13.5％）显示出普遍存在认知障碍的证据。有和没有认知障碍的男性的血浆IGF-1和IGFBP-3浓度相似。然后对3432名无认知障碍的男性进行了长达13年的随访。在此期间，有571人（16.6％）患了痴呆。IGF-1的血浆浓度与痴呆无关。IGFBP-3血浆浓度加倍使痴呆的危险率降低了23％（95％置信区间= 5-37％）。结果不受年龄，体重指数和吸烟史，糖尿病，高血压，冠心病或中风的影响。如果这些发现得到其他人的证实，则IGFBP-3的血浆浓度可用于提高痴呆症预测模型的准确性，并可作为潜在的新因素来帮助制定预防和治疗策略。IGF-1的血浆浓度与痴呆无关。IGFBP-3血浆浓度加倍使痴呆的危险率降低了23％（95％置信区间= 5-37％）。结果不受年龄，体重指数和吸烟史，糖尿病，高血压，冠心病或中风的影响。如果这些发现得到其他人的证实，则IGFBP-3的血浆浓度可用于提高痴呆症预测模型的准确性，并可作为潜在的新因素来帮助制定预防和治疗策略。IGF-1的血浆浓度与痴呆无关。IGFBP-3血浆浓度加倍使痴呆的危险率降低了23％（95％置信区间= 5-37％）。结果不受年龄，体重指数和吸烟史，糖尿病，高血压，冠心病或中风的影响。如果这些发现得到其他人的证实，则IGFBP-3的血浆浓度可用于提高痴呆症预测模型的准确性，并可作为潜在的新因素来帮助制定预防和治疗策略。冠心病或中风。如果这些发现得到其他人的证实，则IGFBP-3的血浆浓度可用于提高痴呆症预测模型的准确性，并可作为潜在的新因素来帮助制定预防和治疗策略。冠心病或中风。如果这些发现得到其他人的证实，则IGFBP-3的血浆浓度可用于提高痴呆症预测模型的准确性，并可作为潜在的新因素来帮助制定预防和治疗策略。