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Carboxymethylpullulan Grafted with Aminoguaiacol: Synthesis, Characterization, and Assessment of Antibacterial and Antioxidant Properties
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-09-01 00:00:00 , DOI: 10.1021/acs.biomac.7b00899 Marie-Carole Kouassi 1 , Pascal Thébault 1 , Christophe Rihouey 1 , Emmanuelle Dé 1 , Béatrice Labat 1 , Luc Picton 1 , Virginie Dulong 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-09-01 00:00:00 , DOI: 10.1021/acs.biomac.7b00899 Marie-Carole Kouassi 1 , Pascal Thébault 1 , Christophe Rihouey 1 , Emmanuelle Dé 1 , Béatrice Labat 1 , Luc Picton 1 , Virginie Dulong 1
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Aminoguaiacol, the aminated derivative of guaiacol, a natural phenolic compound, was chemically grafted onto a polysaccharide (carboxymethylpullulan, CMP) in the presence of the activator agent 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDCI). The grafted polysaccharides were characterized by FTIR and 1H NMR spectroscopy to confirm and quantify the grafting. All polysaccharide derivatives (grafting rates of aminoguaiacol between 16% and 58%) were soluble in water. Their physicochemical properties were studied in a dilute regime and a semidilute regime by light scattering, fluorescence, and rheology, showing associative properties with peculiar polysoap behavior. The antibacterial activities of the synthesized products against Staphyloccocus aureus were assessed using a counting method. The antioxidant activities of the derivatives were also highlighted using the α,α-diphenyl-β-picrylhydrazyl (DPPH) method. Finally, the cytotoxicity of the derivatives was studied with fibroblast cells and they showed a very good cytocompatibility. Such polymers could be used to replace chemical preservatives in food and cosmetic aqueous formulations.
中文翻译：
氨基甲基愈创木酚接枝的羧甲基普鲁兰：合成，表征，和抗菌和抗氧化性能的评估。
在活化剂1-乙基-3-（3-（二甲氨基）丙基）碳二亚胺盐酸盐（EDCI）的存在下，将天然酚类化合物愈创木酚的胺化衍生物氨基愈创木酚化学接枝到多糖（羧甲基普鲁兰（CMP））上。通过FTIR和1 H NMR光谱对接枝的多糖进行表征，以确认和量化接枝。所有的多糖衍生物（氨基愈创木酚的接枝率在16％和58％之间）都可溶于水。通过光散射，荧光和流变学研究了它们在稀薄和半稀薄溶液中的理化性质，显示了与特殊皂液行为相关的性质。合成产物对金黄色葡萄球菌的抗菌活性使用计数方法进行评估。还使用α，α-二苯基-β-吡啶并肼基（DPPH）方法突出了衍生物的抗氧化活性。最后，用成纤维细胞研究了衍生物的细胞毒性，它们显示出非常好的细胞相容性。这样的聚合物可以用来代替食品和化妆品水性制剂中的化学防腐剂。
更新日期：2017-09-04
中文翻译：
氨基甲基愈创木酚接枝的羧甲基普鲁兰：合成，表征，和抗菌和抗氧化性能的评估。
在活化剂1-乙基-3-（3-（二甲氨基）丙基）碳二亚胺盐酸盐（EDCI）的存在下，将天然酚类化合物愈创木酚的胺化衍生物氨基愈创木酚化学接枝到多糖（羧甲基普鲁兰（CMP））上。通过FTIR和1 H NMR光谱对接枝的多糖进行表征，以确认和量化接枝。所有的多糖衍生物（氨基愈创木酚的接枝率在16％和58％之间）都可溶于水。通过光散射，荧光和流变学研究了它们在稀薄和半稀薄溶液中的理化性质，显示了与特殊皂液行为相关的性质。合成产物对金黄色葡萄球菌的抗菌活性使用计数方法进行评估。还使用α，α-二苯基-β-吡啶并肼基（DPPH）方法突出了衍生物的抗氧化活性。最后，用成纤维细胞研究了衍生物的细胞毒性，它们显示出非常好的细胞相容性。这样的聚合物可以用来代替食品和化妆品水性制剂中的化学防腐剂。
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