Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin,ACS Chemical Biology

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Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2017-09-01 00:00:00 , DOI: 10.1021/acschembio.7b00589
Sebastian Götze ₁ , Regine Herbst-Irmer ₂ , Martin Klapper ₁ , Helmar Görls ₃ , Kilian R. A. Schneider ₁ , Robert Barnett ₁ , Thomas Burks ₁ , Ursula Neu ₄ , Pierre Stallforth ₁

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The class of cyclic lipopeptide natural products consists of compounds with a diverse range of bioactivities. In this study, we elucidated the structure of the cyclic lipopeptide anikasin using X-ray crystallography, analyzed its biosynthetic gene cluster, and investigated its natural role in the interaction between the producer strain Pseudomonas fluorescens HKI0770 and protozoal predators. These results led to the conclusion that anikasin has dual functionality enabling swarming motility and acting as a niche amoebicide, which effectively inhibits the social amoeba Polysphondylium violaceum and protects the producer strain from protozoal grazing.

中文翻译：

环状脂肽阿尼卡辛的结构，生物合成和生物活性

环状脂肽天然产物的类别由具有多种生物活性的化合物组成。在这项研究中，我们使用X射线晶体学阐明了环状脂肽阿尼卡辛的结构，分析了其生物合成基因簇，并研究了其在生产菌株荧光假单胞菌HKI0770与原生动物捕食者之间相互作用中的天然作用。这些结果得出结论，anikasin具有双重功能，可促进群体运动并充当小生境杀虫剂，可有效抑制社交变形虫变形虫polysphondylium violaceum并保护生产菌株免受原生动物放牧。

更新日期：2017-09-04

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