Vibrational Profiling of Brain Tumors and Cells,Theranostics

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Vibrational Profiling of Brain Tumors and Cells
Theranostics ( IF 12.4 ) Pub Date : 2017-06-22 , DOI: 10.7150/thno.19172
Sultan L Nelson ₁ , Dustin T Proctor ₂ , Ahmad Ghasemloonia ₂ , Sanju Lama ₂ , Kourosh Zareinia ₂ , Younghee Ahn ₃ , Mustafa R Al-Saiedy ₁ , Francis Hy Green ₄ , Matthias W Amrein ₁ , Garnette R Sutherland ₂

Affiliation

This study reports vibration profiles of neuronal cells and tissues as well as brain tumor and neocortical specimens. A contact-free method and analysis protocol was designed to convert an atomic force microscope into an ultra-sensitive microphone with capacity to record and listen to live biological samples. A frequency of 3.4 Hz was observed for both cultured rat hippocampal neurons and tissues and vibration could be modulated pharmacologically. Malignant astrocytoma tissue samples obtained from operating room, transported in artificial cerebrospinal fluid, and tested within an hour, vibrated with a much different frequency profile and amplitude, compared to meningioma or lateral temporal cortex providing a quantifiable measurement to accurately distinguish the three tissues in real-time. Vibration signals were converted to audible sound waves by frequency modulation, thus demonstrating, acoustic patterns unique to meningioma, malignant astrocytoma and neocortex.

中文翻译：

脑肿瘤和细胞的振动分析

这项研究报告了神经元细胞和组织以及脑肿瘤和新皮质样本的振动概况。设计了一种非接触式方法和分析方案，将原子力显微镜转换为超灵敏麦克风，能够记录和聆听活体生物样本。在培养的大鼠海马神经元和组织中观察到 3.4 Hz 的频率，并且可以通过药理学调节振动。从手术室获取的恶性星形细胞瘤组织样本，在人工脑脊液中运输，并在一小时内进行测试，与脑膜瘤或外侧颞叶皮层相比，以截然不同的频率分布和幅度振动，提供可量化的测量，以准确区分真实的三种组织-时间。通过频率调制将振动信号转换为可听声波，从而展示脑膜瘤、恶性星形细胞瘤和新皮质特有的声学模式。

更新日期：2017-09-04

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