CDK4/6 inhibitors not only induce cell-cycle arrest but also promote antitumor immunity by stimulating the production of type III interferons, which enhance tumor antigen presentation, and suppress regulatory T cells. The immune effects of these drugs provide a rationale for combining CDK4/6 inhibitors with checkpoint blockade agents.

中文翻译：

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CDK4 / 6抑制剂诱导抗肿瘤免疫

CDK4 / 6抑制剂不仅可以诱导细胞周期停滞，而且还可以通过刺激III型干扰素的产生来提高抗肿瘤免疫力，从而增强肿瘤抗原的呈递并抑制调节性T细胞。这些药物的免疫作用为将CDK4 / 6抑制剂与检查点阻断剂结合提供了理论依据。