Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017),Small

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Drug Delivery: Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)
Small ( IF 13.0 ) Pub Date : 2017-09-01 , DOI: 10.1002/smll.201770177
Mónica P. A. Ferreira ₁ , Sanjeev Ranjan _{1,

2} , Sini Kinnunen ₃ , Alexandra Correia ₁ , Virpi Talman ₃ , Ermei Mäkilä _{1,

4} , Brianda Barrios-Lopez ₂ , Marianna Kemell ₂ , Vimalkumar Balasubramanian ₁ , Jarno Salonen ₄ , Jouni Hirvonen ₁ , Heikki Ruskoaho ₃ , Anu J. Airaksinen ₂ , Hélder A. Santos _{1,

5}

Affiliation

Coronary heart disease is the main cause of death worldwide, the endocardium being the most vulnerable region for myocardial ischemia. In article number 1701276, by Mónica P. A. Ferreira, Heikki Ruskoaho, Anu J. Airaksinen, Hélder A. Santos, and co‐workers, the development of a multifunctional nanoparticle with cardioprotective potential is reported, which selectively targets the endocardial layer of the left ventricle upon intravenous injection and delivers a drug molecule for modulating the hypertrophic signaling.

中文翻译：

药物输送：靶向受伤心脏心内膜的载有药物的多功能纳米颗粒可调节肥大信号（Small 33/2017）

冠心病是全世界范围内主要的死亡原因，心内膜是心肌缺血最易受伤害的区域。在MónicaPA Ferreira，Heikki Ruskoaho，Anu J.Airaksinen，HélderA.Santos和同事的文章编号1701276中，报道了具有心脏保护潜能的多功能纳米颗粒的开发，该纳米颗粒选择性靶向左心室的心内膜层在静脉内注射时，并递送用于调节肥大信号的药物分子。

更新日期：2017-09-01

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