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Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly
ChemBioChem ( IF 2.6 ) Pub Date : 2017-09-01 05:05:40 , DOI: 10.1002/cbic.201700425
Lu Yang 1, 2 , Elliott M. Dolan 1, 2 , Sophia K. Tan 2 , Tianyun Lin 2 , Eduardo D. Sontag 2, 3, 4 , Sagar D. Khare 1, 2, 3, 5
Affiliation  

The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.

中文翻译:

刺激响应的多酶超分子组装的计算机引导设计。

受自然多酶组装(代谢物)的启发,代谢途径酶的刺激响应性超分子复合物的构建为有效和时空可控的一锅式生物转化提供了诱人的途径。我们已经构建了对环境污染物1,2,3-三氯丙烷进行生物降解的磷酸化和光学响应代谢产物。
更新日期:2017-09-04
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