Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly,ChemBioChem

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Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly
ChemBioChem ( IF 2.6 ) Pub Date : 2017-09-01 05:05:40 , DOI: 10.1002/cbic.201700425
Lu Yang _{1,

2} , Elliott M. Dolan _{1,

2} , Sophia K. Tan ₂ , Tianyun Lin ₂ , Eduardo D. Sontag _{2,

3,

4} , Sagar D. Khare _{1,

2,

3,

5}

Affiliation

The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.

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