A highly enantioselective conjugate addition reaction of 3-substituted benzothiophen-2-ones to 2-phthalimidoacrylates has been developed using a bifunctional tertiary-amine thiourea catalyst. A number of chiral 3-substituted benzothiophen-2-one compounds were obtained with excellent yields (up to 99%) and very good stereoselectivities (up to >19:1 dr and up to 92% ee). The reaction was proved to be an efficient strategy for the synthesis of enantioenriched α-amino acid derivatives with 1,3-nonadjacent stereogenic centers.

中文翻译：

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3-取代的苯并噻吩-2-酮与2-邻苯二甲酰亚胺基丙烯酸酯的对映选择性共轭加成反应

已经使用双官能叔胺硫脲催化剂开发了3-取代的苯并噻吩-2-酮与2-邻苯二甲酰亚胺基丙烯酸酯的高度对映选择性共轭加成反应。具有优异的产率（高达99％）和非常好的立体选择性（高达> 19获得若干手性3-取代的苯并噻吩-2-酮化合物的：1个博士和高达92％ee）的。该反应被证明是合成具有1,3-不相邻立体异构中心的对映体富集的α-氨基酸衍生物的有效策略。