Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings,Lab on a Chip

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Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings
Lab on a Chip ( IF 6.1 ) Pub Date : 2017-08-29 00:00:00 , DOI: 10.1039/c7lc00851a
Zidong Li _{1,

2,

3,

4} , Erkin Seker _{2,

3,

4,

5}

Affiliation

Advanced biomedical device coatings have shown significant promise in delivery of therapeutics (e.g., small-molecule drugs, proteins) for a wide range of medical interventions ranging from targeted cancer therapy to management of atherosclerosis. In order to accelerate the development of such coatings, there is a need for tools to investigate the loading capacity and release kinetics with high temporal resolution and in a variety of physiological conditions. To address this need, we report a microfluidic platform, where the coating on a substrate can be mounted onto the microchannel and the device can be configured in two physiologically-relevant modes: (i) flow-mode allows for monitoring the release from the coating in contact with a liquid flowing at a specific rate, modeling the case of a drug-eluting stent. (ii) Static-mode, where the channel is filled with a stationary gel, mimics the case of drug-eluting brain implant. We demonstrate the utility of the platform with a fluorescein-loaded nanoporous gold coating and monitor in real-time the release kinetics both under deionized water infusion and an agarose gel-filled channel via fluorescence microscopy coupled to a LabVIEW-based interface.

中文翻译：

可配置的微流体平台，用于研究生物医学设备涂层的治疗效果

先进的生物医学设备涂层在治疗药物的交付方面已显示出巨大的前景（例如，，小分子药物，蛋白质）用于广泛的医疗干预措施，包括针对性的癌症治疗到动脉粥样硬化的治疗。为了加速此类涂层的开发，需要一种工具来研究具有高时间分辨率和在各种生理条件下的负载能力和释放动力学。为了满足这一需求，我们报告了一种微流体平台，该平台上可以将基材上的涂层安装到微通道上，并且可以将设备配置为两种与生理相关的模式：（i）流动模式可监控涂层的释放与以特定速率流动的液体接触，从而模拟药物洗脱支架的情况。（ii）静态模式，其中通道中充满了固定的凝胶，模仿了药物洗脱脑植入物的情况。通过荧光显微镜与基于LabVIEW的界面耦合。

更新日期：2017-09-04

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