Nano/microvehicles for efficient delivery and (bio)sensing at the cellular level,Chemical Science

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Nano/microvehicles for efficient delivery and (bio)sensing at the cellular level
Chemical Science ( IF 7.6 ) Pub Date : 2017-08-21 00:00:00 , DOI: 10.1039/c7sc02434g
S. Campuzano _{1,

2,

3,

4} , B. Esteban-Fernández de Ávila _{5,

6,

7,

8} , P. Yáñez-Sedeño _{1,

2,

3,

4} , J. M. Pingarrón _{1,

2,

3,

4,

9} , J. Wang _{5,

6,

7,

8}

Affiliation

A perspective review of recent strategies involving the use of nano/microvehicles to address the key challenges associated with delivery and (bio)sensing at the cellular level is presented. The main types and characteristics of the different nano/microvehicles used for these cellular applications are discussed, including fabrication pathways, propulsion (catalytic, magnetic, acoustic or biological) and navigation strategies, and relevant parameters affecting their propulsion performance and sensing and delivery capabilities. Thereafter, selected applications are critically discussed. An emphasis is made on enhancing the extra- and intra-cellular biosensing capabilities, fast cell internalization, rapid inter- or intra-cellular movement, efficient payload delivery and targeted on-demand controlled release in order to greatly improve the monitoring and modulation of cellular processes. A critical discussion of selected breakthrough applications illustrates how these smart multifunctional nano/microdevices operate as nano/microcarriers and sensors at the intra- and extra-cellular levels. These advances allow both the real-time biosensing of relevant targets and processes even at a single cell level, and the delivery of different cargoes (drugs, functional proteins, oligonucleotides and cells) for therapeutics, gene silencing/transfection and assisted fertilization, while overcoming challenges faced by current affinity biosensors and delivery vehicles. Key challenges for the future and the envisioned opportunities and future perspectives of this remarkably exciting field are discussed.

中文翻译：

纳米/微车可在细胞水平上高效传递和（生物）传感

提出了有关使用纳米/微载体来解决与细胞水平上的递送和（生物）传感相关的关键挑战的最新策略的观点综述。讨论了用于这些细胞应用的不同纳米/微车辆的主要类型和特性，包括制造途径，推进（催化，磁性，声学或生物）和导航策略，以及影响其推进性能以及传感和传递能力的相关参数。此后，对选定的应用进行了严格的讨论。重点在于增强细胞外和细胞内的生物传感能力，快速的细胞内在化，细胞间或细胞内的快速运动，有效的有效载荷传递和有针对性的按需控制释放，以极大地改善对细胞过程的监控和调节。对选定突破性应用的关键讨论说明了这些智能多功能纳米/微设备如何在细胞内和细胞外水平上作为纳米/微载体和传感器运行。这些进展既可以在单个细胞水平上对相关靶标和过程进行实时生物传感，也可以交付用于治疗，基因沉默/转染和辅助受精的不同货物（药物，功能蛋白，寡核苷酸和细胞），同时克服了这些难题当前的亲和力生物传感器和运载工具面临的挑战。

更新日期：2017-09-04

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