Checkpoint blockade through inhibition of programmed cell death protein 1 (PD1), which enables tumours to evade the immune system, has radically changed the treatment and prognosis of many cancers, especially melanoma. However, a majority of patients do not respond to PD1 inhibition, and great effort

中文翻译：

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癌症免疫疗法：在免疫检查站黑匣子中搜索

通过抑制程序性细胞死亡蛋白1（PD1）来实现检查点封锁，这使肿瘤能够逃避免疫系统，从根本上改变了许多癌症，尤其是黑色素瘤的治疗和预后。但是，大多数患者对PD1抑制均无反应，因此需要付出很大的努力。