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Immunotherapy: CAR T cells in glioblastoma
Nature Reviews Drug Discovery ( IF 122.7 ) Pub Date : 2017-08-11 , DOI: 10.1038/nrd.2017.158
Crunkhorn Sarah

Chimeric antigen receptor-modified T (CAR T) cells have shown efficacy in leukaemia and lymphoma. Now, O'Rourke et al. report on the first clinical trial of CAR T cells targeted to the epidermal growth factor receptor variant III (EGFRvIII) in 10 patients with recurrent glioblastoma.

中文翻译:

免疫疗法:成胶质细胞瘤中的CAR T细胞

嵌合抗原受体修饰的T(CAR T)细胞已显示出在白血病和淋巴瘤中的功效。现在,O'Rourke等人。报道了针对表皮生长因子受体变体III(EGFRvIII)的CAR T细胞在10例复发性胶质母细胞瘤患者中的首次临床试验。
更新日期:2017-09-04
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