Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-related role of place cell dynamics in health and disease remains elusive. Using chronic two-photon Ca²⁺ imaging in hippocampal area CA1 of wild-type and Df(16)A^+/- mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-oriented learning in wild-type mice was supported by stable spatial maps and robust remapping of place fields toward the goal location. Df(16)A^+/- mice showed a significant learning deficit accompanied by reduced spatial map stability and the absence of goal-directed place cell reorganization. These results expand our understanding of the hippocampal ensemble dynamics supporting cognitive flexibility and demonstrate their importance in a model of 22q11.2-associated cognitive dysfunction.

中文翻译：

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在22q11.2缺失的小鼠模型中海马地方细胞动力学受损。

海马位置细胞代表情节性记忆的细胞底物。位置细胞集合重组以支持学习，但还必须保持稳定的表示形式以促进记忆调用。尽管进行了广泛的研究，但与学习相关的位置细胞动力学在健康和疾病中的作用仍然难以捉摸。使用野生型和Df（16）A ^+/-小鼠海马区CA1中的慢性双光子Ca ²⁺成像技术，建立了22q11.2缺失综合征的动物模型，这是认知功能障碍和认知障碍最常见的遗传危险因素之一精神分裂症，我们发现在野生型小鼠中以目标为导向的学习受到稳定的空间图和位置字段向目标位置的强大重新映射的支持。Df（16）A ^+/-小鼠显示出明显的学习缺陷，并伴有空间图稳定性降低和缺乏目标导向的位置细胞重组。这些结果扩展了我们对支持认知灵活性的海马合奏动力学的理解，并证明了它们在22q11.2相关的认知功能障碍模型中的重要性。