A new study reveals an involvement of SLC22A3 in the development of familial oesophageal squamous cell carcinoma (ESCC). Reduced expression of SLC22A3 is detected not only in ESCC tumours but also in non-tumour tissues of patients with familial ESCC. Interestingly, adenosine-to-inosine editing of SLC22A3 mRNA is proposed to drive early tumour invasion and metastasis, by inhibiting SLC22A3 expression.

中文翻译：

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食道癌：SLC22A3 mRNA的RNA编辑：与家族性ESCC有因果关系吗？

一项新研究揭示了SLC22A3参与家族性食管鳞状细胞癌（ESCC）的发展。家族性ESCC患者不仅在ESCC肿瘤中而且在非肿瘤组织中均检测到SLC22A3的表达降低。有趣的是，SLC22A3 mRNA的腺苷到肌苷的编辑被提议通过抑制SLC22A3的表达来驱动早期肿瘤的侵袭和转移。