Letter by El-Battrawy et al Regarding Article, “The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity”,Circulation Research

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Letter by El-Battrawy et al Regarding Article, “The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity”
Circulation Research ( IF 20.1 ) Pub Date : 2017-08-18 , DOI: 10.1161/circresaha.117.311655
Ibrahim El-Battrawy , Siegfried Lang , Martin Borggrefe , Xia-Bo Zhou _{1,

2,

3} , Ibrahim Akin _{1,

2}

Affiliation

The article by Veerman et al¹ published in Circulation Research describing the role of HEY2 in modulation of ion channel expression in Brugada syndrome elicited great interest among members of our research working group. The authors found that the transmural differences of action potential characteristics, I_to (transient outward pottasium current), and I_Na (voltage-dependent sodium current) were diminished in Hey2^+/− mice.

Certainly, it …

中文翻译：

El-Battrawy等人关于文章的信，“ Brugada综合征易感性基因HEY2调节心脏透壁离子通道模式和电异质性”

Veerman等人¹在Circulation Research上发表的文章描述了HEY2在Brugada综合征中调节离子通道表达的作用引起了我们研究小组成员的极大兴趣。作者发现，在Hey2 ^+/-小鼠中，动作电位特性的跨壁差异（I _to（瞬态向外钾电流）和I _Na（电压依赖性钠电流））减小了。

当然，它……

更新日期：2017-08-31

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