Circulation Research ( IF 20.1 ) Pub Date : 2017-08-18 , DOI: 10.1161/circresaha.117.311674 Christiaan C. Veerman 1 , Ronald Wilders 2 , Arthur A. Wilde 1, 3 , Ruben Coronel 1, 4 , Carol Ann Remme 1 , Arie O. Verkerk 1, 2 , Connie R. Bezzina 1
We welcome the opportunity to respond to the question raised by El-Battrawy et al in their letter concerning our study entitled “The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.”1
In their letter, El-Battrawy et al state that the transmural differences observed in Hey2+/− mice as compared with wild-type could be explained by the fact that the sodium current (INa) was measured at room temperature, whereas the transient outward potassium current (Ito) and action potential were evaluated at 36°C. The authors comment that sodium channel expression and sodium current density are modulated by temperature in Brugada Syndrome …
中文翻译：
Veerman等人对Letter关于文章“ Brugada综合征易感性基因HEY2调节心脏透壁离子通道模式和电异质性”的答复
我们欢迎有机会回答El-Battrawy等人在其关于我们的研究的信中提出的问题，该研究题为“ Brugada综合征易感性基因HEY2调节心脏透壁离子通道模式和电异质性”。1个
El-Battrawy等人在信中指出，与野生型相比，Hey2 +/-小鼠中观察到的透壁差异可以通过以下事实解释：在室温下测量钠电流（I Na），而瞬时在36°C下评估了向外钾电流（I to）和动作电位。作者评论说，在Brugada综合征中，钠通道的表达和钠电流密度受温度的调节……
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