Advances in understanding diabetes mellitus (DM) through basic and clinical research have helped clarify and reunify a disease state fragmented into numerous etiologies and subtypes. It is now understood that a common pathophysiology drives the diabetic state throughout its natural history and across its varied clinical presentations, a pathophysiology involving metabolic insults, oxidative damage, and vicious cycles that aggravate and intensify organ dysfunction and damage. This new understanding of the disease requires that we revisit existing diagnostics and treatment approaches, which were built upon outmoded assumptions. 'The Common Pathophysiologic Origins of Diabetes Mellitus and its Complications Construct' is presented as a more accurate, foundational, and translatable construct of DM that helps make sense of the hitherto ambiguous findings of long-term outcome studies.

中文翻译：

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糖尿病及其并发症的统一病理生理结构

通过基础和临床研究在理解糖尿病 (DM) 方面取得的进展有助于澄清和统一分裂为众多病因和亚型的疾病状态。现在已经理解，一个共同的病理生理学驱动糖尿病状态贯穿其自然病史和不同的临床表现，病理生理学涉及代谢损伤、氧化损伤和恶性循环，加重和加剧器官功能障碍和损伤。这种对疾病的新理解要求我们重新审视现有的诊断和治疗方法，这些方法建立在过时的假设之上。“糖尿病的常见病理生理学起源及其并发症结构”被提出为更准确、更基础的、