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The Aging Navigational System.
Neuron ( IF 14.7 ) Pub Date : 2017-Aug-30 , DOI: 10.1016/j.neuron.2017.06.037
Adam W Lester 1 , Scott D Moffat 2 , Jan M Wiener 3 , Carol A Barnes 4 , Thomas Wolbers 5
Affiliation  

The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.

中文翻译:


老化的导航系统。



致力于计算空间信息的神经元系统的发现,由功能不同的细胞类型(如位置细胞和网格细胞)组成,结合大量基于人类的行为和神经影像研究,使我们对大脑的导航回路有了详细的了解。在这篇综述中,我们讨论了来自啮齿动物、非人类灵长类动物和人类的新证据,这些证据证明了认知衰老如何影响这些系统支持的导航计算。重要的是,我们表明:1)导航缺陷不能仅仅用学习和记忆的一般缺陷来解释,2)不同的导航计算之间没有统一的下降,3)导航缺陷可能是即将发生的病理性下降的敏感标志。在介绍了空间导航的机制及其与学习和记忆的一般过程的关系之后,本文讨论了衰老如何影响空间信息的感知和整合、空间信息记忆痕迹的创建和存储以及空间信息的使用。导航行为期间的空间信息。最后部分强调了空间导航的行为和神经标记的临床潜力,特别强调神经退行性疾病。
更新日期:2017-08-31
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