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Specialized Representations of Value in the Orbital and Ventrolateral Prefrontal Cortex: Desirability versus Availability of Outcomes.
Neuron ( IF 14.7 ) Pub Date : 2017-08-30 , DOI: 10.1016/j.neuron.2017.07.042
Peter H Rudebeck 1 , Richard C Saunders 2 , Dawn A Lundgren 2 , Elisabeth A Murray 2
Affiliation  

Advantageous foraging choices benefit from an estimation of two aspects of a resource's value: its current desirability and availability. Both orbitofrontal and ventrolateral prefrontal areas contribute to updating these valuations, but their precise roles remain unclear. To explore their specializations, we trained macaque monkeys on two tasks: one required updating representations of a predicted outcome's desirability, as adjusted by selective satiation, and the other required updating representations of an outcome's availability, as indexed by its probability. We evaluated performance on both tasks in three groups of monkeys: unoperated controls and those with selective, fiber-sparing lesions of either the OFC or VLPFC. Representations that depend on the VLPFC but not the OFC play a necessary role in choices based on outcome availability; in contrast, representations that depend on the OFC but not the VLPFC play a necessary role in choices based on outcome desirability.

中文翻译:

眼眶和前外侧前额叶皮层中的值的专门表示:结果的可取性与可得性。

有利的觅食选择得益于对资源价值的两个方面的估算:资源的当前需求和可利用性。眼眶额区和腹外侧前额区均有助于更新这些估值,但其确切作用仍不清楚。为了探索它们的专长,我们对猕猴进行了两项任务训练:一项要求通过选择性饱足调整来更新预测结果的期望度的表示,另一项要求通过概率来指示结果的可用性的更新表示。我们评估了三组猴子在这两项任务上的表现:未操作的对照组以及OFC或VLPFC有选择性纤维保留病变的对照组。取决于VLPFC但不取决于OFC的代表在基于结果可用性的选择中起着必要的作用;相反,依赖于OFC但不依赖VLPFC的表示在基于结果可取性的选择中起着必要的作用。
更新日期:2017-08-31
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