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Critical Functions of the Lysosome in Cancer Biology
Annual Review of Pharmacology and Toxicology ( IF 11.2 ) Pub Date : 2017-01-06 00:00:00 , DOI: 10.1146/annurev-pharmtox-010715-103101
Shawn M. Davidson 1, 2 , Matthew G. Vander Heiden 1, 2, 3
Affiliation  

Lysosomes (or lytic bodies) were so named because they contain high levels of hydrolytic enzymes. Lysosome function and dysfunction have been found to play important roles in human disease, including cancer; however, the ways in which lysosomes contribute to tumorigenesis and cancer progression are still being uncovered. Beyond serving as a cellular recycling center, recent evidence suggests that the lysosome is involved in energy homeostasis, generating building blocks for cell growth, mitogenic signaling, priming tissues for angiogenesis and metastasis formation, and activating transcriptional programs. This review examines emerging knowledge of how lysosomal processes contribute to the hallmarks of cancer and highlights vulnerabilities that might be exploited for cancer therapy.

中文翻译:


溶酶体在癌症生物学中的关键功能

溶酶体(或裂解体)之所以如此命名是因为它们含有高水平的水解酶。已经发现溶酶体功能和功能障碍在包括癌症在内的人类疾病中起着重要作用。然而,溶酶体促进肿瘤发生和癌症进展的方式仍未被发现。除了充当细胞回收中心外,最近的证据表明,溶酶体还参与能量稳态,为细胞生长,有丝分裂信号传导,启动血管生成和转移形成的组织以及激活转录程序的构建模块。这篇综述探讨了溶酶体过程如何促成癌症特征的新兴知识,并强调了可能被用于癌症治疗的脆弱性。

更新日期:2017-01-06
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