Annual Review of Pharmacology and Toxicology ( IF 11.2 ) Pub Date : 2017-01-06 00:00:00 , DOI: 10.1146/annurev-pharmtox-010716-105010 Bruno Stieger 1 , Zainab M. Mahdi 1 , Walter Jäger 2
Herbal supplements are generally considered safe; however, drug disposition is influenced by the interactions of herbal supplements and food constituents with transport and metabolic processes. Although the interference of herbal supplements with drug metabolism has been studied extensively, knowledge of how they interact with the drug transport processes is less advanced. Therefore, we describe here specific examples of experimental and human interaction studies of herbal supplement components with drug transporters addressing, for example, organic anion transporting polypeptides or P-glycoprotein, as such interactions may lead to severe side effects and altered drug efficacy. Hence, it is clearly necessary to increase the awareness of the clinical relevance of the interference of herbal supplements with the drug transport processes.
中文翻译:
肠和肝细胞转运蛋白:草药补品的治疗作用和药物相互作用
草药补品通常被认为是安全的;然而,药物配置受草药补充剂和食物成分与运输和代谢过程相互作用的影响。尽管已经广泛研究了草药补品对药物代谢的干扰,但是关于它们如何与药物转运过程相互作用的知识尚不成熟。因此,我们在此描述草药补充剂成分与药物转运蛋白(例如,有机阴离子转运多肽或P-糖蛋白)的实验和人类相互作用研究的具体实例,因为这种相互作用可能导致严重的副作用和改变的药物功效。因此,显然有必要提高人们对草药补充剂与药物转运过程的干扰的临床意义的认识。