Considering future clinical transactions, biodegradable and luminescent porous silicon nanoparticles instead of traditional heavy-metal quantum dots have an important significance on the construction of biodegradable and magnetic-fluorescent nanocomposites. Herein, to fabricate PSiNPs@Fe₃O₄ nanocomposites, superparamagnetic iron oxide nanoparticles were covalently incorporated into luminescent porous silicon nanoparticles by microwave-induced hydrosilylation. These resultant nanocomposites had near-infrared fluorescence (500 nm–800 nm) and superparamagnetism with high magnetic saturation value of 141 emu/g. The aqueous-dispersibility of PSiNPs@Fe₃O₄ nanocomposites could be significantly improved via simple ultrasonication in water. Furthermore, they also exhibited an excellent biodegradability and biocompatibility, whether in vitro or in vivo. Finally, their ability of fluorescence/magnetic resonance bimodal imaging had been successfully demonstrated for cancer cells in vitro or tumor tissues in vivo.

中文翻译：

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可生物降解和磁致荧光多孔硅@氧化铁纳米复合材料用于体内肿瘤的荧光/磁共振双峰成像。

考虑到未来的临床交易，可生物降解和发光的多孔硅纳米粒子，而不是传统的重金属量子点，对可生物降解和磁性荧光纳米复合材料的构建具有重要意义。在此，为了制造PSiNPs @ Fe ₃ O ₄纳米复合材料，将超顺磁性氧化铁纳米颗粒通过微波诱导的氢化硅烷化共价结合到发光的多孔硅纳米颗粒中。这些最终的纳米复合材料具有近红外荧光（500 nm–800 nm）和超顺磁性，具有141 emu / g的高磁饱和值。PSiNPs @ Fe ₃ O ₄的水分散性纳米复合材料可通过在水中进行简单的超声处理得到显着改善。此外，无论在体外还是在体内，它们还表现出优异的生物降解性和生物相容性。最后，已经成功地证明了它们的荧光/磁共振双峰成像能力适用于体外癌细胞或体内肿瘤组织。