Exploration of Macroporous Polymeric Sponges As Drug Carriers,Biomacromolecules

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Exploration of Macroporous Polymeric Sponges As Drug Carriers
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-08-31 00:00:00 , DOI: 10.1021/acs.biomac.7b00852
Gaigai Duan ₁ , Amir Reza Bagheri ₁ , Shaohua Jiang ₁ , Jacob Golenser ₂ , Seema Agarwal ₁ , Andreas Greiner ₁

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Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm³/g for the sponges with densities of 3.5 and 6.0 mg/cm³, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (<1500 mg/g). In order to control the release profiles, an additional poly(p-xylylene) (PPX) coating was deposited by chemical vapor deposition on the drug loaded sponge. Consequently, Artemisone (ART) release in the aqueous medium could be retarded, depending on the density of the sponge and the thickness of the coating. In future, the new 3D polymeric sponges would be highly beneficial as drug carriers for the programmed release of drugs for treatment of chronic diseases.

中文翻译：

大孔聚合物海绵作为药物载体的探索

实现高载药量和控制药物输送是与药物载体有关的两个主要挑战。在这项研究中，具有很高的孔体积和大孔隙率的聚合物大孔海绵被引入作为一种新型的药物载体。由于高的孔体积（密度分别为3.5和6.0 mg / cm ³的海绵分别为285和166 cm ³ / g ），海绵具有很高的载药量，平均值为1870±114和2697±73当前研究中的mg / g，远高于中孔和微孔药物载体（<1500 mg / g）。为了控制释放曲线，附加了一个poly（p-二甲苯）（PPX）涂层通过化学气相沉积法沉积在载有药物的海绵上。因此，取决于海绵的密度和涂层的厚度，可以阻止在水介质中释放青蒿素（ART）。将来，新的3D聚合海绵作为药物载体以编程方式释放用于治疗慢性疾病的药物载体将非常有益。

更新日期：2017-08-31

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