Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering,ACS Macro Letters

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Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-08-31 00:00:00 , DOI: 10.1021/acsmacrolett.7b00490
Magdalena Szymusiak ₁ , Joseph Kalkowski ₁ , Hanying Luo ₂ , Alexander J. Donovan ₁ , Pin Zhang ₁ , Chang Liu ₁ , Weifeng Shang ₃ , Thomas Irving ₃ , Margarita Herrera-Alonso ₂ , Ying Liu _{1,

4}

Affiliation

A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Core–shell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, core–shell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.

中文翻译：

小角X射线散射确定的两亲嵌段共聚物和两亲异质接枝聚合物刷组成的胶束的核-壳结构和聚集数

生物医学应用中使用的一大类功能纳米材料，包括靶向药物输送，都依赖两亲性聚合物通过自组装过程封装治疗有效载荷。胶束结构的知识将为聚合物药物输送系统的设计提供关键的见识。由线性双嵌段共聚物聚（乙二醇）-b-聚己内酯（PEG- b -PCL），聚（环氧乙烷）-b-聚乳酸（PEG- b -PLA）组成的核-壳胶束，以及由带有PEG和PLA分支的聚甲基丙烯酸缩水甘油酯骨架组成的异质接枝刷子（PGMA- g-PEG / PLA）通过动态光散射（DLS）和小角X射线散射（SAXS）测量来表征，以获得有关颗粒形态，核-壳尺寸和聚集数的结构信息。在研究聚合物胶束化动力学时，在这种准平衡状态下的结构信息也可以用作参考。

更新日期：2017-08-31

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