Alternatives of treatments for multiple myeloma (MM) have become increasingly available with the advent of new drugs such as proteasome inhibitors, thalidomide derivatives, histone deacetylase inhibitors, and antibody drugs. However, high-risk MM cases that are refractory to novel drugs remain, and further optimization of chemotherapeutics is urgently needed.

We had achieved asymmetric total synthesis of komaroviquinone, which is a natural product from the plant Dracocephalum komarovi. Similar to several leading antitumor agents that have been developed from natural compounds, we describe the antitumor activity and cytotoxicity of komaroviquinone and related compounds in bone marrow cells. Our data suggested that komaroviquinone-related agents have potential as starting compounds for anticancer drug development.

随着诸如蛋白酶体抑制剂，沙利度胺衍生物，组蛋白脱乙酰基酶抑制剂和抗体药物等新药的出现，治疗多发性骨髓瘤（MM）的替代方法越来越多。然而，对于新药难治的高危MM病例仍然存在，迫切需要进一步优化化疗药物。

我们已经实现了komaroviquinone的不对称全合成，而komaroviquinone是植物Dracocephalum komarovi的天然产物。与从天然化合物开发出来的几种领先的抗肿瘤药相似，我们描述了考马罗维醌和相关化合物在骨髓细胞中的抗肿瘤活性和细胞毒性。我们的数据表明，与科马罗维醌有关的药物有可能作为抗癌药物开发的起始化合物。