Three types of sugar modified pyrimido[4,5-b]indole nucleosides (2′-deoxy-2′-fluororibo-, 2′-deoxy-2′-fluoroarabino- and arabinonucleosides) were synthesized by glycosylation of 4,6-dichloropyrimido[4,5-b]indole followed by modification of sugar moiety and introduction of substituents into position 4 by cross-coupling reactions or nucleophilic substitutions. Some 2′-fluororibo- and 2′-fluoroarabinonucleosides displayed interesting anti-HCV activities (IC₅₀ = 1.6–20 μM) and the latter compounds also some anti-dengue activities (IC₅₀ = 10.8–40 μM).

中文翻译：

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糖修饰的嘧啶并[4,5- b ]吲哚核苷：合成与抗病毒活性

通过4,6-二氯嘧啶基的糖基化反应，合成了三种类型的糖修饰的嘧啶并[4,5- b ]吲哚核苷（2'-脱氧-2'-氟核糖-，2'-脱氧-2'-氟阿拉伯糖核苷和阿拉伯糖核苷）。 [4，5- b ]吲哚，其后修饰糖部分，并通过交叉偶联反应或亲核取代将取代基引入位置4。一些2'-氟核糖核苷和2'-氟阿拉伯糖核苷显示出有趣的抗HCV活性（IC ₅₀ = 1.6–20μM），后一种化合物也具有一些抗登革热活性（IC ₅₀ = 10.8–40μM）。