A complementary pair of enantioselective switchable organocatalysts,Chemical Science

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A complementary pair of enantioselective switchable organocatalysts
Chemical Science ( IF 7.6 ) Pub Date : 2017-08-23 00:00:00 , DOI: 10.1039/c7sc02462b
Guillaume De Bo _{1,

2,

3,

4} , David A. Leigh _{1,

2,

3,

4} , Charlie T. McTernan _{1,

2,

3,

4} , Shoufeng Wang _{1,

2,

3,

4}

Affiliation

A pair of enantioselective switchable bifunctional catalysts are shown to promote a range of conjugate addition reactions in up to 95

5 e.r. and 95% conversion. Each catalyst can be switched OFF using conditions that switch the other catalyst ON. Catalyst ON

OFF ratios of up to 98

2 and 1

99 were achieved, with a ratio of reaction rates of up to 16

1 between the ON and OFF states, maintained over complete ON–OFF–ON and OFF–ON–OFF cycles. However, simultaneous operation of the catalyst pair in the same reaction vessel, which in principle could allow product handedness to be switched by simple E–Z isomerisation of the catalyst pair, was unsuccessful. In this first generation complementary pair of enantioselective switchable organocatalysts, the OFF state of one catalyst inhibits the ON state of the other.

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