T helper 17 (T_H17) cells have been extensively studied since their discovery 10 years ago, primarily because of their known pathogenic role in many inflammatory diseases. Substantial progress has been made in understanding their development, regulation and functional activities, and genome-wide transcriptomic analysis has identified regulatory networks, nodes and interactions that provide vital clues for further studies. In this Review, we describe recent studies that have revealed the dichotomous nature of T_H17 cells, which on the one hand allows these cells to be pathogenic drivers of inflammatory disorders and on the other hand allows them to support the integrity of the intestinal barrier in a non-inflammatory manner.

中文翻译：

---

T辅助细胞17细胞的二分性

自从10年前发现T辅助细胞17（T _H 17）细胞以来，就已经对其进行了广泛的研究，这主要是由于其在许多炎症性疾病中的致病作用。在了解它们的发育，调控和功能活性方面已取得了实质性进展，全基因组转录组分析已确定了调控网络，节点和相互作用，为进一步研究提供了重要线索。在这篇综述中，我们描述了最近的研究，这些研究揭示了T _H 17细胞的二分性，一方面使这些细胞成为炎症性疾病的致病性驱动因素，另一方面使它们能够支持肠道屏障的完整性以非炎性的方式。