Atmospheric pressure plasma assisted reaction chemical ionization for analysis of chlorinated compounds separated by liquid chromatography,Journal of Analytical Atomic Spectrometry

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Atmospheric pressure plasma assisted reaction chemical ionization for analysis of chlorinated compounds separated by liquid chromatography
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2017-06-19 00:00:00 , DOI: 10.1039/c7ja00115k
Joseph E. Lesniewski _{1,

2,

3,

4} , William P. McMahon _{1,

2,

3,

4} , Kunyu Zheng _{1,

2,

3,

4} , Haopeng Wang _{1,

2,

3,

4} , Hamid Badiei _{5,

6,

7} , Kaveh Jorabchi _{1,

2,

3,

4}

Affiliation

We report development of an atmospheric pressure plasma assisted reaction chemical ionization (PARCI) source with liquid sample introduction, enabling high sensitivity detection of chlorine in LC-separated compounds. In this novel approach, analytes are introduced into an argon inductively coupled plasma for high-temperature reactions including atomization. The plasma reaction products are then guided into an atmospheric pressure reaction tube where formation of negative ions is enhanced at lower temperatures. Cl⁻ ions emerging from the reaction tube are then detected by an atmospheric sampling single quadrupole mass spectrometer without any modifications. We demonstrate that Cl⁻ ions are generated in PARCI with similar efficiencies between inorganic and organic chlorine-containing compounds, confirming the elemental nature of the ionization for quantitative measurements. We further demonstrate that the ionization reactions within the reaction tube can be controlled by addition of ionization reagents to the plasma. Specifically, we find that addition of low ionization potential elements such as sodium in conjunction with methanol leads to significant enhancements in sensitivity. Chlorine sensitivity and detection limits using LC-PARCI-MS compare favorably with those obtained using state-of-the-art LC-ICP-MS/MS. Operation of PARCI in negative mode alleviates the isobaric interferences for chlorine detection and obviates the need for complex mass analyzers. Notably, the simplicity of PARCI and compatibility with atmospheric sampling mass spectrometers make this approach readily adoptable for integration of elemental quantification with molecular characterization using other ion sources.

中文翻译：

大气压等离子体辅助反应化学电离分析液相色谱法分离的氯化物

我们报告了开发的常压等离子体辅助反应化学电离（PARCI）源，并引入了液体样品，可对LC分离的化合物中的氯进行高灵敏度检测。在这种新颖的方法中，将分析物引入氩气感应耦合等离子体中，以进行包括雾化在内的高温反应。然后将等离子体反应产物导入大气压反应管中，在该反应管中，在较低温度下负离子的形成得到增强。氯^-从反应管新兴离子随后通过没有任何修改的大气采样单四极质谱仪检测。我们表明，氯^-在PARCI中产生的离子在无机和有机含氯化合物之间具有相似的效率，从而证实了用于定量测量的电离的元素性质。我们进一步证明，可以通过向血浆中添加电离试剂来控制反应管内的电离反应。具体来说，我们发现添加低电离势元素（例如钠）和甲醇会导致灵敏度显着提高。使用LC-PARCI-MS测得的氯灵敏度和检出限与使用最新LC-ICP-MS / MS测得的氯灵敏度和检出限相比具有优势。PARCI以负模式运行可减轻氯检测的等压干扰，并且无需使用复杂的质量分析仪。尤其，

更新日期：2017-06-19

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