In the last decade, magnetic nanoparticles (MNPs), especially superparamagnetic iron oxide nanoparticles (SPIONs), have immensely promoted the advancement of diagnostics and theranostics in the biomedical field. Unique properties of SPIONs-core and the functional gold (Au)-shell in consortium (SPIONS/Au core/shell or CS), have a wide range of biomedical applications including but not limited to magnetic resonance imaging (MRI), dual modality MRI/computed tomography (CT), photo-induced and magnetic fluid hyperthermia (MFH), drug delivery, biosensors, and bio-separation. Researchers have made much effort to develop the synthesis strategies for size control and surface modifications to achieve the desired properties of these CSs for applications in in vitro and in vivo studies. This review highlights recent development in the synthesis and biomedical applications of SPIONs/Au CSs including γ-Fe2O3/Au (maghemite), Fe3O4/Au (magnetite), and MFe2O4/Au (M=divalent metal ions) in the past seven years. More importantly, current trends of SPIONs/Au in relation to the biochemical industry are surveyed. Finally, we outline the developmental need of SPIONs/Au with a perspective in material synthesis and their novel applications in disease diagnosis and treatment in the near future.

中文翻译：

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含金核/壳超顺磁性氧化铁纳米粒子的合成，性质和生物医学应用的最新进展

在过去的十年中，磁性纳米颗粒（MNP），尤其是超顺磁性氧化铁纳米颗粒（SPION），极大地促进了生物医学领域诊断学和诊断学的发展。财团中SPIONs核和功能性金（Au）壳的独特特性（SPIONS / Au核/壳或CS）具有广泛的生物医学应用，包括但不限于磁共振成像（MRI），双模式MRI /计算机断层扫描（CT），光诱导和磁流体热疗（MFH），药物输送，生物传感器和生物分离。研究人员付出了很多努力来开发用于尺寸控制和表面修饰的合成策略，以实现这些CS在体外和体内研究中所需的特性。这篇综述重点介绍了过去7年中SPIONs / Au CS的合成和生物医学应用的最新发展，包括γ-Fe2O3/ Au（磁铁矿），Fe3O4 / Au（磁铁矿）和MFe2O4 / Au（M =二价金属离子）。更重要的是，调查了SPIONs / Au与生化工业相关的当前趋势。最后，我们从材料合成的观点及其在不久的将来在疾病诊断和治疗中的新应用概述了SPIONs / Au的发展需求。