Self-Cyclizing Antioxidants to Prevent DNA Damage Caused by Hydroxyl Radical,ChemBioChem

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Self-Cyclizing Antioxidants to Prevent DNA Damage Caused by Hydroxyl Radical
ChemBioChem ( IF 2.6 ) Pub Date : 2017-08-30 05:31:47 , DOI: 10.1002/cbic.201700341
Safnas F. AbdulSalam ₁ , Purujit N. Gurjar ₁ , Haizhou Zhu ₁ , Jing Liu ₁ , Emma S. Johnson ₁ , Ana Luisa Kadekaro ₂ , Julio Landero-Figueroa ₁ , Edward J. Merino ₁

Affiliation

Stable and selective antioxidants: We report a new class of self-cyclizing antioxidants to prevent hydroxyl-radical-mediated DNA damage. The lead agent lowers the levels of reactive oxygen in cells, and prevents the formation of oxazolone lesions (dZ) in cellular DNA upon exposure to oxidative-stress-inducing arsenic trioxide.

中文翻译：