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Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.
The Lancet ( IF 168.9 ) Pub Date : 2017-10-01 , DOI: 10.1016/s2213-2600(17)30294-1
Brendon P Scicluna , Lonneke A van Vught , Aeilko H Zwinderman , Maryse A Wiewel , Emma E Davenport , Katie L Burnham , Peter Nürnberg , Marcus J Schultz , Janneke Horn , Olaf L Cremer , Marc J Bonten , Charles J Hinds , Hector R Wong , Julian C Knight , Tom van der Poll , Friso M. de Beer , Lieuwe D.J. Bos , Jos F. Frencken , Maria E. Koster-Brouwer , Kirsten van de Groep , Diana M. Verboom , Gerie J. Glas , Roosmarijn T.M. van Hooijdonk , Arie J. Hoogendijk , Mischa A. Huson , Peter M. Klein Klouwenberg , David S.Y. Ong , Laura R.A. Schouten , Marleen Straat , Esther Witteveen , Luuk Wieske

Host responses during sepsis are highly heterogeneous, which hampers the identification of patients at high risk of mortality and their selection for targeted therapies. In this study, we aimed to identify biologically relevant molecular endotypes in patients with sepsis.

中文翻译:

根据血液基因组内型对败血症患者进行分类:一项前瞻性队列研究。

败血症期间的宿主反应高度异质性,这阻碍了高死亡率患者的识别以及对靶向治疗的选择。在这项研究中,我们旨在确定败血症患者的生物学相关分子内型。
更新日期:2017-08-30
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