Sepsis is a major cause of illness and death worldwide,¹ and has a complex and heterogeneous disease process that is associated with or caused by a variety of microorganisms and sources of infection. This heterogeneity manifests as a diversity of host responses that occur in different patients,^2–4 making therapeutic management challenging. Evidence-based clinical guidelines for prevention, early identification, and management of sepsis are the only tools available for reducing sepsis prevalence and sepsis-related deaths.

中文翻译：

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脓毒症精准医疗之路：血液转录组内型

脓毒症是全世界疾病和死亡的主要原因¹ ，并且具有复杂且异质的疾病过程，与多种微生物和感染源相关或由多种微生物和感染源引起。这种异质性表现为不同患者发生的宿主反应的多样性，^2-4使得治疗管理具有挑战性。脓毒症预防、早期识别和管理的循证临床指南是减少脓毒症患病率和脓毒症相关死亡的唯一工具。