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Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial.
The Lancet ( IF 98.4 ) Pub Date : 2017-11-01 , DOI: 10.1016/s1473-3099(17)30487-5
Wendelin Moser , Jean T Coulibaly , Said M Ali , Shaali M Ame , Amour K Amour , Richard B Yapi , Marco Albonico , Maxim Puchkov , Jörg Huwyler , Jan Hattendorf , Jennifer Keiser

Preventive chemotherapy is the current strategy to control soil-transmitted helminth infections (caused by Ascaris lumbricoides, hookworm, and Trichuris trichiura). But, to improve efficacy and avoid emerging resistance, new drugs are warranted. Tribendimidine has shown good anthelmintic efficacy and is therefore a frontrunner for monotherapy and combination chemotherapy.

中文翻译:

Tribendimidine,tribendimidine加伊维菌素,tribendimidine加oxantel pamoate和albendazole加oxantel pamoate在坦桑尼亚和科特迪瓦的钩虫和伴随土壤传播的蠕虫感染的功效和安全性:一项随机,对照,单盲,非盲点试验, 。

预防性化学疗法是控制土壤传播的蠕虫感染(由A虫,钩虫和Trichuris trichiura引起)的当前策略。但是,为了提高疗效并避免出现耐药性,必须使用新药。Tribendimidine已显示出良好的驱虫效果,因此是单一疗法和联合化疗的领先者。
更新日期:2017-08-30
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