pH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes,Biomacromolecules

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pH-Sensitive Interactions between Cellulose Nanocrystals and DOPC Liposomes
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-08-29 00:00:00 , DOI: 10.1021/acs.biomac.7b00872
Yotam Navon _{1,

2} , Harisoa Radavidson _{1,

2} , Jean-Luc Putaux _{1,

2} , Bruno Jean _{1,

2} , Laurent Heux _{1,

2}

Affiliation

The interaction of 1,2 dioleolyl-sn-glycero-3-phosphatidylcholine (DOPC) vesicles with cellulose nanocrystals (CNCs) using several complementary techniques. Dynamic light scattering, zeta-potential, cryo-transmission electron microscopy and isothermal titration calorimetry (ITC) analyses confirmed the formation of pH-dependent CNC–liposome complexes. ITC was used to characterize the thermodynamic properties of this interaction. Positive values of enthalpy were found at pH lower than 5 where the charge sign of the constituents was opposite. The association was more pronounced at lower pH, as indicated by the higher values of association constant. We suggest that the positive enthalpy is derived from the release of counterions from the particle hydration shell during the association and that the charge of the vesicles plays a significant role in this interaction.

中文翻译：

纤维素纳米晶体与DOPC脂质体之间的pH敏感相互作用

1,2二油基-sn的相互作用-甘油-3-磷脂酰胆碱（DOPC）囊泡与纤维素纳米晶体（CNCs）的结合，采用了几种互补技术。动态光散射，ζ电位，低温透射电子显微镜和等温滴定热分析（ITC）分析证实了pH依赖性的CNC脂质体复合物的形成。使用ITC来表征这种相互作用的热力学性质。在低于5的pH值（其中组分的电荷符号相反）下发现焓的正值。如较低的缔合常数值所示，缔合在较低的pH下更明显。我们建议，正焓源自缔合过程中粒子水化壳中抗衡离子的释放，并且囊泡的电荷在这种相互作用中起着重要的作用。

更新日期：2017-08-30

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