Geometry lesson: A modular approach for assembling proteins into large-scale geometric structures was developed in which coiled-coil domains acted as “twist ties” to facilitate assembly. The geometry of the cage was specified primarily by the rotational symmetries of the coiled coil and building block protein and was largely independent of protein structural details.

中文翻译：

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由de Novo设计的盘绕线圈介导的四面体蛋白笼的对称定向自组装

几何课：开发了一种将蛋白质组装成大规模几何结构的模块化方法，其中卷曲螺旋结构域充当“扭曲纽带”，以促进组装。笼子的几何形状主要由卷曲的螺旋和构建基块蛋白质的旋转对称性决定，并且在很大程度上与蛋白质的结构细节无关。