Synthesis ( IF 2.2 ) Pub Date : 2017-08-28 , DOI: 10.1055/s-0036-1590893 Sheng Tao 1 , Enhui Ji 1 , Lei Shi 1 , Ning Liu 1 , Liang Xu 1 , Bin Dai 1
S. Tao and E. Ji contributed equally.
Abstract
A copper-catalyzed transfer N-heteroarylation strategy using a C–N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.
A copper-catalyzed transfer N-heteroarylation strategy using a C–N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.
中文翻译:
铜和嘧啶核周围的N-杂环取代基的铜催化C–N键交换
S. Tao和E. Ji的贡献相等。
抽象的
描述了使用C–N键交换反应的铜催化转移N-杂芳基化策略。该反应可容纳范围广泛的带有卤素原子的吡啶和嘧啶环,它们对于随后的转化具有广泛的用途。该方法提供了直接且操作简单的方法,用于通过交换N杂环取代基来修饰复杂分子。
描述了使用C–N键交换反应的铜催化转移N-杂芳基化策略。该反应可容纳范围广泛的带有卤素原子的吡啶和嘧啶环,它们对于随后的转化具有广泛的用途。该方法提供了直接且操作简单的方法,用于通过交换N杂环取代基来修饰复杂分子。