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Symmetrical Trichlorotriazine Derivatives as Efficient Reagents for One-Pot Synthesis of 3-Acetyl-2-chloroquinolines from Acetanilides under Vilsmeier–Haack Conditions
Synlett ( IF 1.7 ) Pub Date : 2017-08-28 , DOI: 10.1055/s-0036-1589099
K. Rajanna , Bhooshan Muddam , P. Venkanna , M. Venkateswarlu , M. Satish Kumar

Symmetrical trichlorotriazine derivatives such as 2,4,6-trichloro-1,3,5-triazine and trichloroisocyanuric acid were explored as Vilsmeier–Haack type reagents in the presence of N,N-dimethylacetamide for the effective synthesis of 3-acetyl-2-chloroquinolines from acetanilides. Ultrasonication led to shorter reaction times than conventional heating and gave yields comparable to those obtained under reflux conditions.

中文翻译:

对称三氯三嗪衍生物作为高效试剂,用于在 Vilsmeier-Haack 条件下从乙酰苯胺一锅法合成 3-Acetyl-2-氯喹啉

对称的三氯三嗪衍生物,如 2,4,6-三氯-1,3,5-三嗪和三氯异氰尿酸在 N,N-二甲基乙酰胺存在下被探索作为 Vilsmeier-Haack 型试剂,用于有效合成 3-乙酰-2 - 来自乙酰苯胺的氯喹啉。超声波导致反应时间比传统加热更短,并且产生的产率与回流条件下获得的产率相当。
更新日期:2017-08-28
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