Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms.

中文翻译：

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优化肌肉疾病患者的胆固醇治疗

他汀类药物通过降低低密度脂蛋白胆固醇 (LDL-C) 对预防心血管事件非常有效。然而，许多服用他汀类药物的患者报告了与肌肉相关的症状，因此无法使用指南推荐的剂量。据报告对他汀类药物不耐受的患者发生心血管事件的风险很高。通过降低 LDL-C 来优化降低心血管风险的临床策略需要应用于经历他们归因于他汀类药物的无法忍受的副作用的患者。在本文中，作者回顾了他汀类药物不耐受的定义，提出了更好地定义他汀类药物不耐受的算法，并描述了在报告他汀类药物相关肌肉症状的个体中优化降低心血管风险的方法。