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Three‐Dimensional Models of the Human Brain Development and Diseases
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-08-28 , DOI: 10.1002/adhm.201700723 Mehdi Jorfi 1 , Carla D'Avanzo 2 , Doo Yeon Kim 2 , Daniel Irimia 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-08-28 , DOI: 10.1002/adhm.201700723 Mehdi Jorfi 1 , Carla D'Avanzo 2 , Doo Yeon Kim 2 , Daniel Irimia 1
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Deciphering the human brain pathophysiology remains one of the greatest challenges of the 21st century. Neurological disorders represent a significant proportion of diseases burden; however, the complexity of the brain physiology makes it challenging to model its diseases. Simple in vitro models have been very useful for precise measurements in controled conditions. However, existing models are limited in their ability to replicate complex interactions between various cells in the brain. Studying human brain requires sophisticated models to reconstitute the tangled architecture and functions of brain cells. Recently, advances in the development of three‐dimensional (3D) brain cell culture models have begun to recapitulate various aspects of the human brain physiology in vitro and replicate basic disease processes of Alzheimer's disease, amyotrophic lateral sclerosis, and microcephaly. In this review, we discuss the progress, advantages, limitations, and future directions of 3D cell culture systems for modeling the human brain development and diseases.
中文翻译：
人脑发育和疾病的三维模型
破译人脑病理生理学仍然是21世纪最大的挑战之一。神经系统疾病占疾病负担的很大一部分；然而，大脑生理学的复杂性使得对其疾病进行建模变得具有挑战性。简单的体外模型对于在受控条件下进行精确测量非常有用。然而，现有模型复制大脑中各种细胞之间复杂相互作用的能力有限。研究人脑需要复杂的模型来重建脑细胞的错综复杂的结构和功能。最近，三维（3D）脑细胞培养模型的进展已经开始在体外重现人脑生理学的各个方面，并复制阿尔茨海默病、肌萎缩侧索硬化症和小头畸形的基本疾病过程。在这篇综述中，我们讨论了用于模拟人脑发育和疾病的 3D 细胞培养系统的进展、优势、局限性和未来方向。
更新日期：2017-08-28
中文翻译：
人脑发育和疾病的三维模型
破译人脑病理生理学仍然是21世纪最大的挑战之一。神经系统疾病占疾病负担的很大一部分；然而，大脑生理学的复杂性使得对其疾病进行建模变得具有挑战性。简单的体外模型对于在受控条件下进行精确测量非常有用。然而，现有模型复制大脑中各种细胞之间复杂相互作用的能力有限。研究人脑需要复杂的模型来重建脑细胞的错综复杂的结构和功能。最近，三维（3D）脑细胞培养模型的进展已经开始在体外重现人脑生理学的各个方面，并复制阿尔茨海默病、肌萎缩侧索硬化症和小头畸形的基本疾病过程。在这篇综述中，我们讨论了用于模拟人脑发育和疾病的 3D 细胞培养系统的进展、优势、局限性和未来方向。
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