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A 2,4′-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2017-06-28 , DOI: 10.1038/ja.2017.72
Henki Rotinsulu , Hiroyuki Yamazaki , Tomohito Miura , Satomi Chiba , Defny S Wewengkang , Deiske A Sumilat , Michio Namikoshi

In the course of our research on protein tyrosine phosphatase (PTP) 1B inhibitors, we identified a new 2,4′-linked tetrahydroxanthone dimer (1), named secalonic acid F1 (Figure 1a) in the culture broth of the Okinawan freshwater fungus Aspergillus sp. TPU1343.

中文翻译:

来自冲绳淡水曲霉属物种的具有蛋白质酪氨酸磷酸酶1B抑制活性的2,4'-连接的四氢黄酮二聚体。

在我们研究蛋白质酪氨酸磷酸酶(PTP)1B抑制剂的过程中,我们在冲绳淡水真菌曲霉曲霉的培养液中发现了一个新的2,4'-连接的四氢黄酮二聚体(1),名为secalonic acid F1(图1a)。 sp。TPU1343。
更新日期:2017-08-28
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