Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids,ACS Macro Letters

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Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-08-25 00:00:00 , DOI: 10.1021/acsmacrolett.7b00492
Amedea Manfredi ₁ , Nicolò Mauro ₂ , Alessio Terenzi ₂ , Jenny Alongi ₁ , Federica Lazzari ₁ , Fabio Ganazzoli ₃ , Giuseppina Raffaini ₃ , Elisabetta Ranucci ₁ , Paolo Ferruti ₁

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This paper reports on synthesis, acid–base properties and pH-dependent structuring in water of d-, l- and d,l-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N′-methylenebis(acrylamide). The circular dichroism spectra of d- and l-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribution at pH 6 and 14 consistent with the similarity of the CD spectra from pH 6 upward.

中文翻译：

d-和l-精氨酸衍生的聚酰胺氨基酸的自排序二级结构

本文报道了d -, l - 和d , l -ARGO7在水中的合成、酸碱性质和 pH 依赖性结构，这是由相应的精氨酸立体异构体与N , N '-亚甲基双(丙烯酰胺)加聚获得的仿生聚合物. d - 和l的圆二色光谱-ARGO7 在 228 nm 处显示一个峰值，并且对 pH 变化做出快速且可逆的响应，但几乎不受温度、离子强度和变性剂的影响。L-ARGO7 的理论建模研究表明它具有折叠结构。分子内相互作用导致主链的反式排列让人想起蛋白质发夹基序。扭转角在 pH 6 和 14 处显示出非常相似的分布，这与从 pH 6 向上的 CD 光谱的相似性一致。

更新日期：2017-08-25

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