Fluazaindolizine suspension concentrate (500 g L⁻¹ SC), as a pre-commercialized product, was firstly investigated under open-field conditions. A sensitive method for simultaneous determination of fluazaindolizine and seven metabolites (IN-QEK31, IN-F4106, IN-A5760, IN-UJV12, IN-UNS90, IN-QZY47 and IN-TMQ01) was established and validated using HPLC-QqQ-MS/MS technique. The LOQs of these pollutants in tomato were 0.01 mg kg⁻¹, and their recoveries were 81.1%–117% with the relative standard deviations (RSDs < 11.8%). The dissipation behaviours of fluazaindolizine in soil followed first-order kinetics with the half lives of 4.6–32.4 days, whilst the residues in plant were below its LOQ after 7 days. The fluazaindolizine residues in soil were below 0.963 mg kg⁻¹, based on root irrigation applications (50–75 mg a.i. per plant) twice and pre-harvest interval (PHI, 3 days), while the residues of IN-QEK31, IN-F4106 and IN-A5760 were below 3.9 mg kg⁻¹, excluding other four metabolites ( < 0.01 mg kg⁻¹). The residues of fluazaindolizine in tomato were below 0.01 mg kg⁻¹, and IN-QEK31 remained 0.135 mg kg⁻¹. The current study could not only guide reasonable usage of the formulation, but also facilitate the setting of residue definition and its maximum residue limits (MRLs) of fluazaindolizine in tomato.

中文翻译：

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基于HPLC-QqQ-MS / MS技术的SAX SPE程序研究氟氮嗪及其七种代谢产物在番茄生态系统中的耗散行为和残留分布

首先在露天条件下研究了预商品化的Fluazaindolizine悬浮浓缩液（500 g L ^-1 SC）。建立了同时测定fluazaindolizine和7种代谢物（IN-QEK31，IN-F4106，IN-A5760，IN-UJV12，IN-UNS90，IN-QZY47和IN-TMQ01）的灵敏方法并使用HPLC-QqQ-MS进行了验证/ MS技术。番茄中这些污染物的最低定量限为0.01 mg kg ^-1，其回收率为81.1％–117％，相对标准偏差（RSD <11.8％）。fluazaindolizine在土壤中的耗散行为遵循一阶动力学，半衰期为4.6-32.4天，而植物中的残留物在7天后低于其LOQ。土壤中的fluazaindolizine残留量低于0.963 mg kg ^-1，基于两次根灌应用（每株植物50-75 mg ai），两次收获前间隔时间（PHI，3天），而IN-QEK31，IN-F4106和IN-A5760的残留量低于3.9 mg kg ^-1，不包括其他四种代谢物（<0.01 mg kg ^-1）。番茄中氟氮嗪的残留量低于0.01 mg kg ^-1，IN-QEK31仍为0.135 mg kg ^-1。当前的研究不仅可以指导制剂的合理使用，而且可以帮助确定番茄中氟氮杂吗啉的残留定义及其最大残留限量（MRL）。