Receptor Targeted Polymeric Nanostructures Capable of Navigating across the Blood-Brain Barrier for Effective Delivery of Neural Therapeutics,ACS Chemical Neuroscience

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Receptor Targeted Polymeric Nanostructures Capable of Navigating across the Blood-Brain Barrier for Effective Delivery of Neural Therapeutics
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2017-08-25 00:00:00 , DOI: 10.1021/acschemneuro.7b00207
Taru Dube ₁ , Sonika Chibh ₁ , Jibanananda Mishra ₂ , Jiban Jyoti Panda ₁

Affiliation

The window of neurological maladies encompasses 600 known neurological disorders. In the past few years, an inordinate upsurge in the incidences of neuronal ailments with increased mortality rate has been witnessed globally. Despite noteworthy research in the discovery and development of neural therapeutics, brain drug delivery still encounters limited success due to meager perviousness of most of the drug molecules through the blood-brain barrier (BBB), a tight layer of endothelial cells that selectively impedes routing of the molecules across itself. In this Review, we have tried to present a comprehensive idea on the recent developments in nanoparticle based BBB delivery systems, with a focus on the advancements in receptor targeted polymeric nanoparticles pertaining to BBB delivery. We have also attempted to bridge the gap between conventional brain delivery strategies and nanoparticle based BBB delivery for in-depth understanding. Various strategies are being explored for simplifying delivery of molecules across the BBB; however, they have their own limitations such as invasiveness and need for hospitalization and surgery. Introduction of nanotechnology can impressively benefit brain drug delivery. Though many nanoparticles are being explored, there are still several issues that need to be analyzed scrupulously before a real and efficient BBB traversing nanoformulation is realized.

中文翻译：

受体靶向的聚合物纳米结构能够穿越血脑屏障，以有效地输送神经治疗药物

神经系统疾病的窗口涵盖了600种已知的神经系统疾病。在过去的几年中，全球范围内目睹了神经疾病发病率的急剧上升和死亡率的上升。尽管在神经疗法的发现和开发方面进行了值得注意的研究，但由于大多数药物分子通过血脑屏障（BBB）的渗透性很差，因此脑部药物的递送仍然取得了有限的成功。分子跨越自身。在这篇综述中，我们试图就基于纳米粒子的BBB递送系统的最新发展提出一个全面的想法，重点是与BBB递送有关的受体靶向聚合物纳米颗粒的发展。我们还试图弥合常规脑部递送策略与基于纳米颗粒的BBB递送之间的差距，以进行深入了解。为了简化分子在血脑屏障中的传递，正在探索各种策略。但是，它们有其自身的局限性，例如侵入性以及需要住院和手术。纳米技术的引入可以显着受益于脑部药物的输送。尽管正在探索许多纳米粒子，但是在实现真正有效的BBB遍历纳米配方之前，仍然需要认真分析几个问题。他们有自己的局限性，例如侵入性，需要住院和手术。纳米技术的引入可以显着受益于脑部药物的输送。尽管正在探索许多纳米粒子，但是在实现真正有效的BBB遍历纳米配方之前，仍然需要认真分析几个问题。他们有自己的局限性，例如侵入性，需要住院和手术。纳米技术的引入可以显着受益于脑部药物的输送。尽管正在探索许多纳米粒子，但是在实现真正有效的BBB遍历纳米配方之前，仍然需要认真分析几个问题。

更新日期：2017-08-25

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