Abstract

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgCl·LiCl or TMP₂Zn·2MgCl₂·2LiCl leading to the corresponding metallated derivatives. These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO₂Et, or MeSO₂SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives.

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgCl·LiCl or TMP₂Zn·2MgCl₂·2LiCl leading to the corresponding metallated derivatives. These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO₂Et, or MeSO₂SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives.

中文翻译：

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使用TMP碱对功能化的甲硅烷基化氰醇的锌离子和镁离子的放大作用

摘要

多官能甲硅烷基化的氰醇很容易用TMPMgCl·LiCl或TMP ₂ Zn·2MgCl ₂ ·2LiCl镁化或镀锌，生成相应的金属化衍生物。这些Mg或Zn衍生物与各种亲电试剂反应，例如苄基溴化物，烯丙基溴化物，酰氯，醛，NCCO ₂ Et或MeSO ₂ SMe。随后，TBAF-脱保护提供相应的酮或1，2-二酮衍生物。

多官能甲硅烷基化的氰醇很容易用TMPMgCl·LiCl或TMP ₂ Zn·2MgCl ₂ ·2LiCl镁化或镀锌，生成相应的金属化衍生物。这些Mg或Zn衍生物与各种亲电试剂反应，例如苄基溴化物，烯丙基溴化物，酰氯，醛，NCCO ₂ Et或MeSO ₂ SMe。随后，TBAF-脱保护提供相应的酮或1，2-二酮衍生物。