Designing Pd–N-Heterocyclic Carbene Complexes for High Reactivity and Selectivity for Cross-Coupling Applications,Accounts of Chemical Research

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Designing Pd–N-Heterocyclic Carbene Complexes for High Reactivity and Selectivity for Cross-Coupling Applications
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-08-24 00:00:00 , DOI: 10.1021/acs.accounts.7b00249
Robert D. J. Froese ₁ , Christopher Lombardi ₂ , Matthew Pompeo ₂ , Richard P. Rucker ₂ , Michael G. Organ _{2,

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Affiliation

Over the past decade, the use of Pd–NHC complexes in cross-coupling applications has blossomed, and reactions that were either not previously possible or possible only under very forcing conditions (e.g., > 100 °C, strong base) are now feasible under mild conditions (e.g., room temperature, weak base). Access to tools such as computational chemistry has facilitated a much greater mechanistic understanding of catalytic cycles, which has enabled the design of new NHC ligands and accelerated advances in cross-coupling. With these elements of rational design, highly reactive Pd–NHC complexes have been invented to catalyze the selective formation of single products in a variety of transformations that have the potential to afford multiple compounds (e.g., isomers).

中文翻译：

设计Pd-N-杂环碳烯配合物以实现高反应性和交叉偶联应用的选择性

在过去的十年中，Pd-NHC络合物在交叉偶联应用中的应用日渐盛行，在以前的条件下（例如，> 100°C，强碱），以前不可能发生的反应或仅在非常强迫的条件下才可能发生的反应温和的条件（例如，室温，弱碱）。可以使用诸如计算化学之类的工具来促进对催化循环的更深入的机械理解，这使得能够设计新的NHC配体并加快了交叉偶联的进展。通过合理设计的这些要素，已经发明了高反应性的Pd-NHC复合物，以催化在各种转化中选择性生成单一产物的可能性，这些转化有可能提供多种化合物（例如异构体）。

更新日期：2017-08-24

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